Research - TCH - Medical Oncology - Clinical trials
PERUSE:A Multicentre, open-label, single-arm study of pertuzumab in combination with trastuzumab and a taxane in first line treatment of patients with HER2-positive advanced (metastatic or locally recurrent) breast cancer.
Symptom Benefit: Does Palliative Chemotherapy Improve Symptoms in Women with Recurrent Ovarian Cancer? Measuring subjective improvement as well as objective response to estimate the benefit of palliative chemotherapy in women with platinum resistant or refractory ovarian cancer (ANZGOG-0701/GCIG)
PARAGON – A phase II study of aromatase inhibitors in women with potentially hormone responsive recurrent / metastatic gynaecological neoplasms
BRAIN TRAIN: Evaluation of a Cognitive Rehabilitation Programme in Cancer Survivors with Self Reported Cognitive Impairment
SCOT: Short Course Oncology Therapy-A study of adjuvant chemotherapy in colorectal cancer (12 weeks versus 24 weeks oxaliplatin and 5FU).
TRACC:Prospective Study of clinical outcomes and analysis of bevacizumab use in metastatic colorectal cancer: BioGrid Project
GAP: Phase II study of Gemcitabine and nab-Paclitaxel for Resectable Pancreas Cancer.
RESILIENCE: A phase III randomised, double blind, placebo-controlled trial comparing plus sorafenib versus capecitabine plus placebo in the treatment of locally advanced or metastatic HER2-negative breast cancer.
ctDNA: Circulating Tumour DNA as a Marker of Occult Disease in Stage II Colorectal Cancer and Response to Therapy in Metastatic Colorectal cancer.
ASCENT: An Australian Translational Study to Evaluate the Prognostic Role of Inflammatory Markers in Patients with Metastatic Colorectal Cancer Treated with Bevacizumab (Avastin TM).
CATCHEZ:Continuous Access to advanced and metastatic renal cell Carcinoma therapy with Everolimus post pazopanib treatment
AFFINITY: A randomised Phase 3 Study Comparing Cabazitaxel/Prednisone in Combination with Custirsen (OGX-011) to Cabazitaxel/Prednisone for Second-line Chemotherapy in Men with Metastatic Castrate Resistant Prostate Cancer
EVEREXES: A phase IIIb, multi-centre, open-label, expanded access study of Everolimus (RAD001) in combination with Exemestane in post-menopausal women with estrogen receptor positive, human epidermal growth factor receptor 2 negative locally advanced or metastatic breast cancer
Mitotane: Mitotane Pharmacodynamics in Adrenocortical Cancer in Children and Adults
MORab – 004: A Phase II study of the safety and efficacy of the combination of Gemcitabine and Docetaxel with MORab-004 in metastatic soft tissue sarcoma
DETERMINE: A Phase 2, Randomized, Double-blind Study Comparing Tremelimumab to Placebo in Second-or Third-line Treatemnt of Subjects with Unresectable Pleural or Peritoneal Malignant Mesothelioma
PROSPER: A Phase 4, Randomized, Double-Blind, Placebo Controlled Study of Continued Enzalutamide Treatment beyond Progression in Patients with Chemotherapy-Naïve, Metastatic-Castration Resistant Prostate Cancer:
Clinical Research Staff
Desmond Yip, Director, Medical Oncology Research Unit
Olive Doig, RN, Clinical Trials Manager.
Anne Ryan, RN, Clinical Trials Coordinator
Jody Berry, RN, Clinical Trials Coordinator
Edward Craft, Administrative Assistant
Phone (02) 6244 3688.
Dr Christine Hemmings RGON, BHB, MBChB, FRCPA, ST John of God Pathology, Subiaco WA.
Dr Douglas Taupin, PhD FRACP, Department of Gastroenterology, Canberra Hospital.
Dr Anneke Blackburn, BSc PhD, John Curtin School of Medical Research
Research Grants Held
Prof R. Stuart-Harris. Prospective evaluation of cognitive impairment in women receiving adjuvant chemotherapy for early breast cancer. The Canberra Region Medical Foundation
Stuart-Harris R. The Development of a Clinical Palliative Index for the Treatment of Advanced Cancer. The Private Practice Fund, The Canberra Hospital
Stuart-Harris R. Coping Styles and Severity of Toxicity from Adjuvant Chemotherapy for Early Breast Cancer or Colorectal Cancer. Cancer Council ACT.
Yip D. A Cancer Clinical Trials Research Programme in the ACT. Cancer Council ACT.
Yip D, Budge M, Taupin D, Nolan C. Installation and implementation of Bio21:MMIM (Molecular Medicine Informatics Model now known as BioGrid Australia) in Canberra. TCH Radiation Oncology Private Practice Trust Fund.
Haydon A, Zalcberg J, Walpole E, Yip D, Price T, Howard K, Jefford M. Short Course Oncology Therapy- A study of Adjuvant Chemotherapy in Colorectal Cancer by the CACTUS and OCTO Groups. Cancer Australia Priority driven Collaborative Cancer Research Scheme.
Yip D, Dahlstrom J, Jain S, Barry P, Carpenter J, Clarke C. Westmead Millenium Institute, University of Sydney. The Breast Cancer Tissue Bank: establishment of collection site for collection, storage and transfer of human blood and tissue samples in the ACT.